Latest Articles

DNA Methylation Clocks test result blog post

Ageotypes, Sex and Individual Differences in Longevity

Your Ageotype: How You Age, Individually Ageing biology is mind-blowingly complex. Stepping back from the minute details and thousands of interacting molecular pathways, we age in broad categories. Stanford Professor Michael Snyder coined the term ‘Ageotypes’. It describes four broad categories of ageing. They are metabolic ageing, immune aging and specific ageing for liver and kidney functions. You have a unique profile of how you…

Sugar: Glucose, Fructose and Sucrose

Get to Know Your Sugar for Smart Longevity Diet Choices Let’s get one thing clear. Fructose and Glucose (while both sugar) are not the same thing. Sure, they are made of the same chains of chemicals. The difference is in the number of molecules forming each sugar. Fructose has a ring of five and glucose has a ring of six. This small difference translates into…

The Brick Wall of Ingrained Health Beliefs (why the Age Well Times is not for Everyone)

You Can’t Convince Everyone that Healthy Ageing is Possible, and I Won’t Try I vividly remember the first time my healthy ageing knowledge and reality clashed head-on. It involved an older relative. We were discussing my plans for a new project – which would later become this website – and I was enthusiastically sharing what I had learned about longevity science and recent breakthroughs. My…

Review of Why We Sleep by Matthew Walker

You’d be hard pushed to find anyone that understands sleep as deeply as Matthew Walker. As a neuroscience and psychology professor at the University of California, Berkeley, he runs the Centre for Human Sleep Science there. Matthew Walker is high-profile in the media. He is a popular guest on high profile podcasts, and now hosts his own. His book ‘Why We Sleep’ is a mix…

Pathways associated with morning UV exposure

Yamanaka Factors and Longevity Research

Cellular Reprogramming Research Won Shinya Yamanaka a Nobel Prize Shinya Yamanaka won the Nobel Prize for Medicine in 2012 for a remarkable longevity breakthrough, his discovery of Yamanaka Factors. . He discovered a way to turn regular adult cells into Pluripotent Stem Cells. When stem cells divide, they specialise – replenishing the myriad cell types which are essential for a healthily functioning body. The four…

The Great Dog N Roll Swindle

Five Reasons the World’s Oldest Dog Record is a Simple Scam I get it, in a world full of war, recession and viruses – we all love a good news story. That said, I’m convinced that the story of Bobi, the world’s oldest dog is a simple publicity stunt. You can’t blame Guinness World Records here. After all, their new business model is to charge…

Metformin and Longevity

Metformin Reduces Incidence of Deadly Diseases – Does it Also Slow Ageing? Metformin was prescribed 92 million times in the US and 22 million in the UK (based on 2020 figures). It is prescribed to people with type 2 diabetes. It works on multiple pathways – effectively lowering blood sugar levels, reducing atherosclerosis, and protecting against certain cancers. First prescribed in 1958, Metformin is safe.…

Peter Attia: Four Types of Death

Peter Attia Split Death into Four Types: Death, Cognitive Death, Physical Death and Emotional Death The edition of the ‘Drive,’ podcast where Peter Attia described the four types of death, is a powerful episode. To start with, nobody explains the difference between lifespan and health span better than Peter. When you look beyond the obvious death, there are three more ways to die. They are…

Zinc and Longevity

Zinc is Vital for Immune Response, Cellular Signalling, and Vision Zinc deficiency is dangerous. That danger increases as we age. Zinc is essential to immune health, reducing inflammation and boosting brain health. It is one of many elements that cause significant problems when you are deficient in them. The risks of supressed immune response, lower vaccine responses and chronic low-level inflammation are higher in in…

Jellyfish Age Backwards Detailed Book Review

Jellyfish Age Backwards Book Review

Jellyfish Age Backwards by Nicklaus Brendborg is an entertaining broad-based introduction to healthy ageing and longevity. Rather than following the ‘hard science’ style of many books in the longevity field, Jellyfish Age Backwards introduces the core concepts via stories and examples from the animal kingdom. For the first 50 pages, I wondered whether I was the right audience. Despite the clever weaving of stories from…

Biological Age Test Worries

My Biological Age Test is Coming Soon – So Why am I Worried? After publishing my detailed overview of biological age tests, my own test is on the way. I was not expecting the worry. You see, there are multiple reasons why I might be biologically older than my fifty-two chronological years. While I have been actively building on healthy habits for two years now,…

Testing Your Biological Age

Circuits Around the Sun and Your Biological Age are Not the Same Thing: Here is Why This Matters Measuring your biological age is more than just a vanity metric. It solves a fundamental challenge of testing longevity drugs and healthy lifestyle interventions. We simply live too long for clinical trials to conclusively say whether an intervention works. This is why we use proxies for age,…

Nine Hallmarks of Ageing

How the Agreed Hallmarks of Ageing Interact How old you are and how many times Planet Earth has flown around the Sun are not the same thing. People born on the same day can have a hugely different biological age decades later. While the number of candles on your birthday cake are an accurate measure of chronological age (depending on how polite your friends and…

Sulforaphane and Longevity

Up Your Antioxidant Game with Broccoli, Cabbage, and Sprouts I had to dig deep into clinical papers to get reliable information on Sulforaphane and longevity. Most ‘scientific’ articles on this topic are shilling a supplement offer. It is hard not be biased when your income is linked to sales of the substance covered… That aside, Sulforaphane is showing significant promise. Papers show that it is…

The Collagen Cure Book Review

Detailed Review of the Collagen Cure by Dr. James DiNicolantonio and Siim Land I bought the Collagen Cure after enjoying to Siim Land’s podcasts on longevity science, this is my detailed review. The key take-away is that collagen is not the simple skin scaffolding I had assumed. In fact, as the work of Dr. James DiNicolantonio shows, it has a vital role in the health…

Testing for biological age vs chronological age

Ageless: Detailed Book Review

Detailed Review of Ageless: The New Science of Getting Older Without Getting Old By Andrew Steele Coming back to Ageless by Andrew Steele for this detailed review was an eye-opener. I first read it alongside other longevity science books in a flurry of enthusiasm and note-taking. It only took thirty pages of my second reading before the penny dropped – Ageless is excellent. The…

How I Tumbled Down the Longevity Science Rabbit Hole: From Lifespan to the Age Well Times

I’m excited, and grateful. After all, not everyone gets to take a new direction in life in their early 50’s. Sixteen years ago, I quit my moderately successful corporate career, and learned to write. I’m still learning. Along the way I’ve created websites and ghost-written thousands of pieces for clients. Objectively, it looked like my switch from blue-chip to free-spirit was a success. Yet, something…

Longevity Habits

Longevity Habits: The Big Benefits of Healthy Ageing, Without Becoming a Half-Starved Fitness Fanatic After multiple successes, failures and (ongoing) battles with sugar cravings – I have implemented healthy ageing and longevity habits covering sleep, exercise, food, fasting, mindset, and lifestyle. I vividly remember the sense of overwhelm the first time I went down the healthy aging rabbit hole. My initial enthusiasm came from reading…

Longevity and Healthy Ageing Supplements

Beyond Generic Longevity Supplement Advice: Safety, Effectiveness and Personalisation If you took all the recommended longevity supplements to boost your healthy ageing – you’d rattle. In fact, overdoing levels of many common vitamins and minerals will accelerate your ageing. An ideal setup is that you take exactly the supplements you need for optimal health, based on feedback from your own body. Blood tests help. However,…

Alcohol and Longevity

Is Any Amount of Alcohol Safe for Healthy Aging and Longevity? Alcohol is so ingrained in our lives that objectively assessing its role in healthy aging and longevity needs steely determination to remain objective. I’ll admit to being a wine lover. Even though it’s not my personal ‘demon’ (that’s sugar), giving up wine would be a major negative for my quality of life. However, alcohol…

Latest Articles

Mark’s Blog

Science

Lifestyle

Nutrition

People